Amid news reports of "ghoul" attacks nearby, Ken Kaneki is interested in Rize, a girl at a local coffee shop. When Kaneki discovers the two share a favorite author, he asks her out. However, their date ends in tragedy!
Kaneki fights the urge to eat human flesh, the only thing that can satisfy his hunger as a ghoul. He meets up with Hide again, joining him on an errand, and is glad for the companionship. But will his declining condition place Hide at risk?
Yoshimura teaches Kaneki more about how to blend in with mankind and takes in a mother and daughter needing protection. Two ghoul investigators are assigned to the 20th Ward. In response, Touka takes Kaneki out to have a mask made for him.
Kaneki starts receiving self-defense lessons from Yomo. He meets Itori, who runs her own bar, and is friends with Uta and Yomo. Kaneki is befriended by Tsukiyama, a ghoul who knew Rize, who also enjoys reading and possesses epicurean tastes.
When Touka falls ill, Kaneki pays her a visit that has unexpected consequences. Meanwhile, as Nishiki is recovering from his run-in with Kaneki, he is nearly preyed upon by other ghouls. Tsukiyama remains consumed with the idea of having Kaneki.
After Kaneki and Hinami witness Ryoko's fate, the personnel at Anteiku are grieved, and Touka decides to take matters into her own hands. Kaneki is fed up with not being able to do anything, and makes up his mind to become involved.
Touka sets out to lure the ghoul investigators, but before she can strike, she finds that Hinami has run away. When Touka and Kaneki go looking for her, they come face to face with Amon and Mado, who has a few surpises of his own for them.
After several weeks go by, everyone tries to return to their normal lives. Hinami moves in with Touka, and despite her aversion to birds, they nurse an injured cockatiel back to health. Kaneki visits Itori to try to learn more about Rize.
The 11th Ward offices of CCG are attacked by ghouls, wiping everyone out. Banjo and company stop in at Anteiku to warn Rize about a new group of ghouls bent on taking over—until Kaneki accidentally knocks him out!
Kaneki is held captive by Yamori, who practices his torturous craft on him. The police and CCG move in to deal with Aogiri Tree, who have made a shopping mall their headquarters. In all the commotion, the Anteiku team tries to rescue Kaneki.
As Shinohara and Kuroiwa prepare to take on the Owl, Amon insists on joining the battle. Ayato attacks Touka, and Kaneki comes to her rescue. Meanwhile, Yomo, Tsukiyama, and Uta take on Noro, but find him to be a most unusual opponent.
A CCG prison bus is attacked by Aogiri Tree members. At Anteiku, Touka and Hinami find out that Kaneki is involved in the attack, but each react to the news in different ways, prompting Hinami to try to be less of an imposition upon Touka.
After living together at a CCG children's home years earlier, Kurona, Nashiro, and Suzuya are reunited in combat at Cochlea. Ayato faces a battle against Shinohara, who is equipped with armor created from the remnants of his father, Arata.